Although the Flood can infect most organic organism with complex enough central nervous systems, they tend to prefer assimilating sapient organisms. The Flood is extremely virulent, and once a Flood infestation has made itself known, it is near impossible to prevent its spread throughout the world which it has infected.
The Flood is not like anything seen in the Milky Way as it is actually an extragalactic organism. The Flood are a parasitic organism from the Halo universe with the sole purpose of consuming/infecting sentient organisms of sufficient biomass, and cognitive capability. Infection forms attack Master Chief Source:
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